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There were 180 subjects(77.3%)with negative,25(15.0%)with low positive,and 18(7.7%)with moderately high positive aCL titers.The frequency and extent of focal and diffuse brain abnormalities were not related to the aCL status of those examined.However,subjects with positive aCL results performed worse than those with negative findings on almost all tests administered,and this effect was mainly IgG titer related.When an ANCOVA test and partial correlations to correct for slight group differences in age and for the presence of major vascular risk factors were used,values of P<.05 were noted on tests assessing mnemonic and visuopractical abilities.Increased aCL titers in normal elderly persons may be associated with subtle neuropsychological dysfunction,but they do not appear to cause any morphological changes as demonstrated by MRI. |
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